Clinical study of Yiqi-Huoxue-Tongmai Decoction combined with conventional western medicine in the treatment of diabetic lower extremity arteriosclerosis obliterans
10.3760/cma.j.cn115398-20191114-00096
- VernacularTitle:益气活血通脉汤结合西医常规疗法治疗糖尿病下肢动脉硬化闭塞症临床研究
- Author:
Liping ZHAI
1
;
Xu WANG
Author Information
1. 江苏省泰州市中医院内分泌科 225300
- From:
International Journal of Traditional Chinese Medicine
2020;42(11):1069-1073
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of Yiqi-Huoxue-Tongmai Decoction combined with conventional western medicine therapy in the treatment of diabetic lower extremity arteriosclerosis obliterans. Methods:A total of 80 patients with diabetic lower extremity arteriosclerosis obliterans in Taizhou Hospital of TCM from March 2017 to March 2019 who met the inclusion criteria were divided into the control group of 39 cases and study group of 41 cases, by random number table method. The control group was treated by intravenous injection of alprostadil injection and oral cilostazol tablets, and the study group was given Yiqi-Huoxue-Tongmai Decoction on the basis of the control group. Both groups were treated for 1 month. Fasting plasma glucose (FPG) and 2 hPG content were measured by glucose oxidase method, the TNF-α, IL-1 and hypersensitive C-reactive protein (hs-CRP) were measured by immunoturbidimetric method. Plasma viscosity and whole blood viscosity were measured by viscometer. Fibrinogen (Fib) level was measured by microcalorimetry. ESR was measured by Wintrobe method. The diameter of dorsalis pedis artery and superficial femoral artery, blood flow and peak velocity were measured by color doppler ultrasound, and adverse reactions were recorded, and the clinical efficacy was evaluated. Results:The total effective rate of the study group was 90.2% (37/41) and that of the control group was 71.8% (28/39). The difference between the two groups was statistically significant ( χ2=4.466, P=0.035). After treatment, the levels of FPG, 2 hPG, TNF-α, IL-1 and hs-CRP in the study group were significantly lower than those in the control group ( t values were 6.113, 4.180, 7.655, 2.825, 2.534, respectively, P<0.01 or P<0.05); the plasma viscosity, whole blood viscosity, Fib and ESR were significantly lower than those in the control group ( t values were 5.649, 9.894, 15.280, 3.455, respectively, all Ps<0.01). After treatment, the vessel diameter of the superficial femoral artery and dorsalis pedis artery ( t values were 4.184, 4.415, respectively) and blood flow ( t values were 2.253, 7.859, respectively) in the study group were significantly higher than those in the control group ( P<0.01 or P<0.05), and the peak flow velocity was significantly lower than that of the control group ( t=6.346, 6.427, P<0.01). Conclusions:Yiqi-Huoxue-Tongmai Decoction combined with conventional western medicine therapy can improve the blood glucose level and hypercoagulable state of patients with diabetic lower extremity arteriosclerosis obliterans, as well as the blood flow velocity and blood flow of superficial femoral artery and dorsal foot artery.
