Advances of Krüppel-like factors in hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2020.02.012
- VernacularTitle:Krüppel样因子在肝癌中的研究进展
- Author:
Chuanxi ZHAO
1
;
Tingting ZHU
;
Mingguo LIU
;
Lili CAO
Author Information
1. 山东第一医科大学第一附属医院(山东省千佛山医院)肿瘤科 山东第一医科大学(山东省医学科学院)，济南 250014
- From:
Journal of International Oncology
2020;47(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Krüppel-like factors (KLFs) play extremely important roles in genesis and development of tumors. Simultaneously, KLFs have been proven to affect the proliferation, differentiation and migration of hepatocellular carcinoma cells. Nine members in the KLFs family (KLF2, KLF4, KLF5, KLF6, KLF8, KLF9, KLF10, KLF14 and KLF17) are involved in the occurrence and development of hepatocellular carcinoma in various ways as an oncogene and tumor suppressor gene. Therefore, the KLFs family will hopefully become biological therapeutic targets for hepatocellular carcinoma.
