Research progress in the effect of placental growth factor on pregnancy
10.3760/cma.j.cn121382-20191110-00215
- VernacularTitle:胎盘生长因子对妊娠影响的研究进展
- Author:
Hongmei GU
1
;
Xiaowen CHAI
Author Information
1. 天津市滨海新区妇女儿童保健和计划生育服务中心 300459
- From:
International Journal of Biomedical Engineering
2020;43(2):166-170
- CountryChina
- Language:Chinese
-
Abstract:
Placental growth factor (PLGF) is isolated and purified from human placental complementary DNA (cDNA) library, and syncytiotrophoblast cells are the main synthesis site. PLGF can bind to tyrosinase receptors located in trophoblast cells and vascular endothelial cells, and regulate trophoblast cell proliferation through autocrine and paracrine regulation of angiogenesis, respectively. PLGF plays an extremely important role in the formation and development of the placenta during pregnancy. The abnormal secretion of PLGF is closely related to the occurrence and progression of pregnancy complications (such as pregnancy complicated with diabetes, hypertension in pregnancy, preeclampsia, etc.). In this paper, the structure, receptor, biological activity of PLGF and its relationship with normal pregnancy and pregnancy complications were reviewed to provide references for clinical guidance and auxiliary diagnosis of pregnancy complications.
