Research progress in the relationship between intestinal flora and tumor immunotherapy
10.3760/cma.j.cn121382-20191103-00214
- VernacularTitle:肠道菌群与肿瘤免疫治疗关系的研究进展
- Author:
Baozhong ZHANG
1
;
Jingjing ZHAO
;
Wencheng ZHANG
;
Qingsong PANG
Author Information
1. 天津医科大学肿瘤医院放疗科,国家肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心 300060
- From:
International Journal of Biomedical Engineering
2020;43(2):161-165
- CountryChina
- Language:Chinese
-
Abstract:
There are various bacterial colonies in the human intestine, which play an important role in the maintenance of human intestinal function and the maintenance of the systemic immune system. After years of research, researchers have found that intestinal flora are closely related to a variety of inflammatory and immune diseases. In recent years, immunotherapy has attracted more and more attention in the treatment of malignant tumors. In these immunotherapy researches, researchers have found that the composition and changes of intestinal flora can affect the efficacy of tumor immunotherapy to a certain extent. In this paper, the literatures related to intestinal flora and tumor immunotherapy were reviewed from four aspects including the relationship between intestinal flora and body's immune mechanism, current status of tumor immunotherapy, correlation research between intestinal flora and tumor immunotherapy, and related factors that affect changes in intestinal flora composition. The researches on intestinal flora and tumor immunotherapy in the past ten years were mainly summarized. The analysis results showed that the intestinal flora plays an important role in the body's immune mechanism and is closely related to the efficacy of tumor immunotherapy.
