Circular RNAs and acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2020.05.013
- VernacularTitle:环状RNAs与急性缺血性卒中
- Author:
Lei ZUO
1
;
Honghong YAO
;
Fuling YAN
Author Information
1. 东南大学附属中大医院神经内科，南京 210009
- From:
International Journal of Cerebrovascular Diseases
2020;28(5):386-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In recent years, circular RNAs (circRNAs) related to stroke has been widely studied, and its change involves multiple pathophysiological aspects of stroke, including angiogenesis, neural plasticity, cell apoptosis, and neuroinflammation. Further exploration of the changes of specific circRNAs after acute ischemic stroke and the molecular biological mechanisms involved will help to develop possible new drug targets and improve the prognosis of patients. This article reviews the main circRNAs that have changed after acute ischemic stroke, and their mechanism of action, functional detection methods, and challenges faced by the current research.
