Role and mechanism of activating transcription factor 4 in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2020.03.013
- VernacularTitle:转录激活因子4在脑缺血中的作用及其机制
- Author:
Meiyan CHEN
1
;
Haixia WEN
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科 510260
- From:
International Journal of Cerebrovascular Diseases
2020;28(3):227-232
- CountryChina
- Language:Chinese
-
Abstract:
Activating transcription factor 4 (ATF4) is a stress response factor containing a basic region-leucine zipper. When the body is under stress, the increased expression of ATF4 binds to cellular transcription factors, which in turn regulates the corresponding downstream target genes, thereby initiating cellular responses. After cerebral ischemia, ATF4 plays a neuroprotective role by participating in various pathophysiological processes such as regulating endoplasmic reticulum stress, oxidative stress, mitochondrial autophagy, inflammatory response, vascular regeneration, and synaptic plasticity. Therefore, ATF4 is expected to become a new target for the treatment of ischemic brain injury.
