Construction methods and current status of Staphylococcus aureus animal models
10.3760/cma.j.issn.1673-4408.2020.10.013
- VernacularTitle:金黄色葡萄球菌感染动物模型的构建方法及现状
- Author:
Chen SUN
1
;
Suyun QIAN
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院重症医学科 100045
- From:
International Journal of Pediatrics
2020;47(10):731-735
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus aureus(S.aureus)causes a wide range of human infections, ranging from mild skin and soft tissue infections(SSTIs)to various life-threatening invasive infections(such as bacteremia, sepsis, osteomyelitis, endocarditis, necrotizing pneumonia, etc.). The increasingly severe drug resistance of S. aureus makes the clinical treatment face great challenges.In addition to standardizing the use of antibiotics, new drugs and strategies for the treatment of S. aureus infections need to be developed.Constructing an animal model of S. aureus infection is conducive to exploring the pathogenic mechanism of S. aureus and the development of new antibacterial drugs.This review will elaborate on species selection, modeling methods, detection indicators, advantages and disadvantages of animal models, with a view to providing reference for the selection and preparation of animal models of S. aureus infections.
