Advances in the correlation between HDAC8 gene and idiopathic pulmonary fibrosis
10.3760/cma.j.issn.1673-4408.2020.08.003
- VernacularTitle:HDAC8基因与特发性肺纤维化相关性的研究进展
- Author:
Yanping ZHANG
1
;
Donghong PENG
Author Information
1. 重庆医科大学附属儿童医院呼吸科，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童发育重大疾病国家国际科技合作基地 400016
- From:
International Journal of Pediatrics
2020;47(8):528-530
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of idiopathic pulmonary fibrosis has been increasing year by year.Although traditional drugs have been shown to be effective in preventing process of pulmonary fibrosis, their side effects are high and application is limited.Cell, cytokine, and epithelial-mesenchymal transition all participate in the process of pulmonary fibrosis, and HDAC8 also plays an important role in these related processes.The researchers found that HDAC8 contributes to pulmonary fibrosis, and that HDAC8 inhibitors have the potential to treat IPF and other fibrotic lung diseases.In this paper, the research progress of the relationship between HDAC8 gene and idiopathic pulmonary fibrosis in recent years is reviewed.
