The role of fructose in children with nonalcoholic fatty liver disease
10.3760/cma.j.issn.1673-4408.2020.06.011
- VernacularTitle:果糖在儿童非酒精性脂肪肝中的机制研究进展
- Author:
Jing XIA
1
;
Yanyan GAO
;
Yang LIU
;
Yanan MA
;
Deliang WEN
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004；中国医科大学健康科学研究院，沈阳 110122
- From:
International Journal of Pediatrics
2020;47(6):420-424
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) refers to a chronic, obesity-related liver disease, which has become one of the most common liver diseases in children.NAFLD is also regarded as the liver symptom of metabolic syndrome in children, which is closely related with obesity, insulin resistance, abnormal lipid metabolism and even cardiovascular-related disease in children.Therefore, it is noteworthy to provide more concerns and efficiency strategies regarding prevention and treatment of NAFLD in children.Previous studies have shown that abnormal fructose metabolism could play an essential role in the physiopathological process of NAFLD.Here in, this study aims to perform the comparation of the similarities and differences regarding fructose metabolism in liver under physiological and pathological conditions, in addition, to clarify the problems and challenges that need to be overcome in clinical studies and bench work related to NAFLD.
