Progress in Prevention and Treatment of Diabetic Complications with Breviscapine
10.13422/j.cnki.syfjx.20200737
- VernacularTitle:灯盏花素防治糖尿病并发症的研究进展
- Author:
Li-jiao XU
1
;
Xu ZHANG
1
;
Rong-chang CHEN
2
;
Yue ZHU
1
;
Xiao-bo SUN
2
;
Gui-bo SUN
2
Author Information
1. School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, China
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
- Publication Type:Research Article
- Keywords:
breviscapine;
diabetes;
research progress;
mechanism of action;
combination
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(7):218-224
- CountryChina
- Language:Chinese
-
Abstract:
Erigeron breviscapus, a species within the genus of Erigeron, is mainly distributed in Southwest China. It is cold in property, slightly bitter in taste, and has the effect of dispersing cold table, removing wind and dehumidification, promoting blood circulation and removing blood stasis, relieving pain and inflammation. Breviscapine is the extract of E. breviscapus. It is mainly consisted of flavonoids, lignans, coumarins, terpenes, phytosterols, etc. As the major components of breviscapine, the content of breviscapine b (4′-hydroxybaicalin-7-O-glucuronide) and breviscapine a (apigenin-7-O-glucuronide) is greater than 90%. Modern pharmacological studies have shown that breviscapine has a wide range of pharmacological effects, including anti-oxidation, anti-fibrosis, anti-inflammation, anti-aging, anti-platelet aggregation, lowering blood lipid, increasing blood flow, improving microcirculation, preventing and treating tumors, and resisting brain injury. In clinical, breviscapine has been widely used in the treatment of diabetes, cerebral insufficiency, sequelae caused by cerebral hemorrhage, hypermucolipemia, cerebral thrombosis, kidney disease, liver disease, Alzheimer's disease, and some other complex diseases. Specially, in the treatment of diabetes and its chronic complications, such as diabetic nephropathy, diabetic cardiomyopathy, diabetic foot, diabetic retinopathy, breviscapine has showed significant efficacy. In addition, studies have demonstrated that the combined application of breviscapine, mecobalamine, and micopol can improve the therapeutic effect. In this work, the application of breviscapine in the treatment of chronic complications of diabetes mellitus and its related combination drugs were reviewed, by which we attempted to provide some valuable clues for the clinical application of breviscapine in the treatment of diabetes mellitus and its chronic complications.
