Effect of Traditional Chinese Medicines in Treatment of Post-traumatic Stress Disorder
10.13422/j.cnki.syfjx.20200507
- VernacularTitle:中药治疗创伤后应激障碍的研究进展
- Author:
Qiu-yu LI
1
;
Jian-you GUO
2
;
Zi-wei YAO
1
;
Xiao-mei WANG
1
;
Jin-li SHI
1
Author Information
1. School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China
2. Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
- Publication Type:Research Article
- Keywords:
post-traumatic stress disorder;
traditional Chinese medicine(TCM) monomers;
single TCM extracts;
TCM compounds
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(7):211-217
- CountryChina
- Language:Chinese
-
Abstract:
Post-traumatic stress disorder (PTSD) is a mental disorder characterized by restitution of trauma and emotional irritability and avoidance caused by sudden, threatening or catastrophic life events. PTSD occurs not only abnormal behavioral indicators but also abnormal neurobiological indicators. Studies on the pathogenesis of PTSD have focused on neuroendocrine system, central nervous system and immune system, mainly finding abnormal levels of stress hormones, pro-inflammatory cytokines, neurotransmitters and neuroprotective factors. Traditional Chinese medicines(TCM) have many advantages in the treatment of PTSD due to their multi-target, multi-component and multi-pathway characteristics. Current studies have showed that a variety of TCM can improve the abnormal behaviors of animals in the models of post-traumatic stress disorder and reverse the neurobiological indicators. As many of these TCM compounds have been used in clinic and have good efficacy, TCM treatment of PTSD has a broad application prospect. However, there is no specific medicine for PTSD, and its mechanisms have not been fully understood. Therefore, this paper reviews the current studies on the treatment of PTSD with TCM, and focuses on the occurrence and treatment progress of PTSD in terms of TCM, mechanisms of action and animal models, so as to provide references for the treatment of PTSD.
