Research progress of STAT3 inhibitors
10.12206/j.issn.1006-0111.202006024
- VernacularTitle:信号转导及转录激活因子3抑制剂研究进展
- Author:
Hang LIU
1
;
Qinjie ZHAO
2
;
Wei XU
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350100, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
STAT3;
inhibitor;
antitumor
- From:
Journal of Pharmaceutical Practice
2021;39(1):4-8
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription 3 (STAT3) is a signal transcription protein that exists in the cytoplasm. The abnormal activation of STAT3 is closely related to cell proliferation, differentiation, and canceration. It has abnormal expression in cancer stem cells such as breast cancer, pancreatic cancer, lymphoma, and lung cancer. Therefore, inhibiting the abnormal expression of STAT3 has become a new approach for antitumor therapy.
