A new cadinane-type sesquiterpenoid from Eupatorium adenophorum Spreng
10.16438/j.0513-4870.2020-1302
- VernacularTitle:紫茎泽兰中一个新的杜松烷型倍半萜
- Author:
Xu LIANG
1
;
Xin-zhou YANG
2
;
Chao-qun WU
2
;
Yu-zhao LI
2
;
Jing-quan YUAN
1
Author Information
1. Guangxi University of Chinese Medicine, Nanning 530200, China
2. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China
- Publication Type:Research Article
- Keywords:
italic>Eupatorium adenophorum Spreng;
chemical constituent;
cadinane-type sesquiterpenoid;
alien invasive plant
- From:
Acta Pharmaceutica Sinica
2020;55(12):2955-2959
- CountryChina
- Language:Chinese
-
Abstract:
Four cadinane-type sesquiterpenes were obtained from the petroleum ether of 95% ethanol extract of Eupatorium adenophorum Spreng by using an HP-20 macroporous resin column, silica gel, and semi-preparative HPLC. Their structures were determined by physical, chemical and spectroscopic methods and identified as eupatorinol (1), (+)-(5R,7S,9R,10S)-2-oxocadinan-3,6(11)-dien-12,7-olide (2), (1S,4R)-7-hydroxycalamenen-3-one(3) and (-)-(5R,6R,7S,9R,10S)-cadinan-3-ene-6,7-diol (4). Among them, compound 1 is a new cadinane-type sesquiterpene, and compound 3 was isolated from this genus for the first time. In bioassay, none of these compounds displayed obvious cytotoxicity.
