Expression and biological significance of GABRE in colon cancer: An analysis based on data mining of Oncomine and TCGA databases
DOI：10.3872/j.issn.1007-385X.2020.12.014
- VernacularTitle:基于Oncomine和TCGA数据库分析GABRE在结肠癌组织中的表达及生物学意义
- Author:
YANG Jiani1,2
1
,
2
;
BAI Yibing1,2
1
,
2
;
CUI Ying1,2
1
,
2
;
LIAN Jie1,2
1
,
2
;
WU Feng2,3
3
,
4
;
HANG Yanqiao1,2
1
,
2
Author Information
1. Department of Oncology, Cancer Hospital Affiliated to Harbin Medical University, Harbin 150081, Heilongjiang, China;
2. Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, Heilongjiang, China
3. Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, Heilongjiang, China;
4. Department of Gastroenterology, the First Clinical Hospital Affiliated to Harbin Medical University, Harbin 150001, Heilongjiang, China
- Publication Type:Journal Article
- Keywords:
GABRE gene;
colon cancer;
Oncomine database;
TCGA database;
prognosis;
biomarker
- From:
Chinese Journal of Cancer Biotherapy
2020;27(12):1399-1405
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To explore the expression and biological significance of GABRE gene in colon cancer by mining data in the Oncomine and TCGA databases. Methods: The expression of the GABRE gene in colon cancer tissues and its correlation with the prognosis of patients were analyzed using the Oncomine and TCGA databases. The upstream miRNA targeting GABRE gene was identified using TargetScan, starBase, mirDIP, and miRWalk, and its expression and relationship with prognosis of colon cancer were analyzed. Furthermore, the GABRE co-expression genes were screened using the LinkedOmics database, and the GO enrichment analysis and KEGG pathway analysis were carried out. Results: The results showed that GABRE was highly expressed in colon cancer and indicated a poor prognosis (all P<0.05). The Venn diagram indicated that hsa-miR-370-3p targeted GABRE, and its expression was markedly increased in normal tissues (P<0.01). The expression of GABRE was positively correlated with the expressions of OGT and FAM156A genes, whereas negatively correlated with the expressions of ATP5A1 and MPDU1 genes (all P<0.05). GO biological process function and KEGG pathway enrichment analysis suggested that the GABRE gene may be involved in biological processes including protein dealkylation and regulation of cyclin-dependent protein kinase activity and enriched in taurine metabolism and NF-κB signaling pathway. Conclusions: GABRE gene is highly expressed in patients with colon cancer and indicates a poor prognosis, suggesting that the gene may serve as a potential novel target for the diagnosis and treatment of colon cancer.
- Full text:202012142.pdf
