Advances in Research on Relationship Between Fusobacterium nucleatum and Cancer
10.3969/j.issn.1008-7125.2019.02.013
- Author:
Yifan LIAN
1
Author Information
1. Department of Gastroenterology, Zhongshan Hospital, Xiamen University
- Publication Type:Journal Article
- Keywords:
Fusobacterium nucleatum;
Intestinal Microflora;
Neoplasms
- From:
Chinese Journal of Gastroenterology
2019;24(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
The disturbance of intestinal flora is closely related to the development of tumors. Studies showed that oral symbiotic strain Fusobacterium nucleatum was significantly enriched in a variety of tumors and promoted the disease progression, indicating poor prognosis of patients. Molecular mechanism studies found that Fusobacterium nucleatum could activate host cell cancer-related signaling pathways, trigger chronic inflammation, and suppress immune surveillance to enhance cancer cell proliferation, invasion, metastasis and anti-apoptosis. This article reviewed advances in research on relationship between Fusobacterium nucleatum and cancer.
