Value of quantitative and heterogeneous analysis of radionuclide myocardial perfusion in diagnosis of viral myocarditis
10.13929/j.1003-3289.201903063
- Author:
Zilong DENG
1
Author Information
1. Department of Nuclear Medicine, Xiangya Hospital, Central South University
- Publication Type:Journal Article
- Keywords:
Heterogeneity;
Myocarditis;
Myocardium;
Radionuclide imaging
- From:
Chinese Journal of Medical Imaging Technology
2019;35(11):1652-1656
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the value of quantitative and heterogeneous analysis of radionuclide myocardial perfusion in diagnosis of viral myocarditis (VMC). Methods: 99mTc-MIBI myocardial perfusion imaging data of 37 patients suspected with VMC were analyzed retrospectively. Eighteen patients were clinical diagnosed as VMC (VMC group) and 19 patients excluded VMC were served as non-VMC group. Summed rest score (SRS) and the total perfusion deficit (TPD) were obtained by using QPS software. Heterogeneity parameters of radioactive count (segmental coefficient of variation [CVs] and ventricular wall coefficient of variation [CVw]) were also calculated. Perfusion parameters were compared between the two groups, and the diagnostic value on discrimination of VMC patients was evaluated by ROC analysis. Results: Compared with non-VMC group, myocardial perfusion in anterior and inferior walls decreased significantly in VMC group (all P<0.05); TPD and CVs were significantly higher in VMC group (P<0.05). Efficiency of CVs in diagnosis of VMC was best (AUC=0.83, P<0.01). When the threshold of CVs was 10.5%, the diagnostic sensitivity was 94.4% and the specificity was 73.7%. Conclusion: Heterogeneous analysis of myocardial perfusion is helpful for differential diagnosis of VMC.
