Risk Factors for New Onset Diabetes after Transplantation among Renal Transplant Recipients Treated with Tacrolimus.
- Author:
Yu Kyong CHOI
1
;
Ye Jee KIM
;
Nam Kyong CHOI
;
Min Young KIM
;
Na Na BAEK
;
Ji Youn YOUM
;
Jung Eun LEE
;
Dae Joong KIM
;
Yoon Goo KIM
;
Ha Young OH
;
Wooseong HUH
Author Information
1. Sungkyunkwan University College of Medicine, Division of Nephrology, Samsung Medical Center, Korea. wooseong.huh@samsung.com
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Diabetes mellitus;
Tacrolimus
- MeSH:
Body Mass Index;
Diabetes Mellitus;
Glucose;
Hepatitis B;
Humans;
Incidence;
Kidney Transplantation;
Polyomavirus;
Polyomavirus Infections;
Rejection (Psychology);
Risk Factors;
Tacrolimus;
Tissue Donors;
Transplants
- From:Korean Journal of Nephrology
2010;29(6):761-767
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was conducted to identify risk factors for new onset diabetes after transplantation (NODAT) among renal transplant recipients treated with tacrolimus-based immunosuppressant. METHODS: We selected renal transplant recipients who underwent surgery at Samsung Seoul Hospital between May 2001 and July 2009. Exclusion criteria were as follows: recipients <18 years old, history of diabetes mellitus (DM) or impaired glucose tolerance. Analysis of possible risk factors for NODAT included age, gender, body mass index, co-morbid diseases, family history of DM, infection of hepatitis B or polyomavirus, type of donors (cadaver or living) and acute rejection. Overall incidence and median value of NODAT onset day were analyzed with Kaplan-Meier curve. We calculated crude incidence rate and relative risk (RR) and 95% confidence interval (CI) for independent risk factors of NODAT using Cox proportional hazard analysis. RESULTS: A total of 278 patients were included and the incidence of NODAT was 13.3% (5.6/100 person-year) and the median duration of NODAT onset was 28 days. In Cox analysis, risk factors for NODAT were age (45-59 years: RR=1.41, 95% CI 1.09-1.83, 60> years: RR=4.36, 95% CI 2.00-9.49), family history of DM (RR=1.62, 95% CI 1.12-2.34) and polyomavirus infection (RR=1.40, 95% CI 1.08-1.81). CONCLUSION: The risk factors for NODAT among renal transplant recipients treated with tacrolimus-based regimen were age (>45 years old), family history of DM and polyomavirus infection.
