Exploration of prognostic factors of castration-resistant prostate cancer patients
10.7501/j.issn.0253-2670.2018.24.022
- Author:
Rui-Yu MOU
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Castration-resistant prostate cancer;
Cholesterol;
Overall survivial (OS);
Prognosis influencing factors;
Progression free survival (PFS)
- From:
Chinese Traditional and Herbal Drugs
2018;49(24):5882-5888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors of castrated resistant prostate cancer (CRPC). Methods From December 1, 2015 to November 30, 2017, CRPC patients who met the inclusion criteria were collected from the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tumor Hospital of Tianjin Medical University, and General Hospital of Tianjin Medical University. The reliability and validity of 18 included factors were analyzed. The Kaplan-Meier method was used to screen the prognostic factors of CRPC and draw the survival curve.The significant fators from single factor analysis were included in COX proportional risk model for multiple-factor analysis to determine the independent prognostic factors. Results Hematuria, osteodynia, HGB < 120 g/L, CHO > 5.18 mmol/L, TPSA > 10 ng/mL, f/tPSA > 0.19, deficiency of both qi and blood, and no treatment of combination of traditional Chinese medicine were the risk factors for overall survival (OS) in CRPC patients; CHO > 5.18 mmol/L was the only risk factor for OS in CRPC patients, which was established as risk factors. CHO > 5.18 mmol/L, HGB < 120 g/L, and deficiency of both qi and blood were the risk factors for progression free survival (PFS) in CRPC patients, but they were not independent risk factors for PFS in CRPC patients. Conclusion CHO > 5.18 mmol/L is an independent risk factor for OS in CRPC patients.
