Effects of Hydralazine Pretreatment on Esmolol-induced Controlled Hypotension during Spine Surgery.
10.4097/kjae.2006.50.6.S31
- Author:
Kum Suk PARK
1
;
Young Jin ROH
;
Jong Su KIM
;
Sang Hwan DO
Author Information
1. Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. shdo@snu.ac.kr
- Publication Type:Original Article
- Keywords:
controlled hypotension;
esmolol;
hydralazine
- MeSH:
Arterial Pressure;
Cardiac Output;
Heart Rate;
Humans;
Hydralazine*;
Hypotension;
Hypotension, Controlled*;
Spine*
- From:Korean Journal of Anesthesiology
2006;50(6):S31-S35
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Controlled hypotension improves surgical field and decreases transfusion requirement in surgical patients and can be induced with various kinds of drugs including esmolol and hydralazine. METHODS: This study examined the effect of a combination of esmolol and hydralazine as hypotensive agents in spine surgery. In the esmolol group (n = 15), after boluses of esmolol (0.5 mg/kg) injection, esmolol was infused to maintain the mean arterial pressure of 55-65 mmHg. In the hydralazine-esmolol group (n = 15), hydralazine (0.3 mg/kg) was administered 15 minutes before esmolol injection which was done in the same way as that of the esmolol group. RESULTS: The mean arterial pressure decreased to the target range more rapidly in the hydralazine-esmolol group. The heart rate was increased by hydralazine, but reduced by esmolol. The cardiac output remained elevated after hydralazine injection in the hydralazine-esmolol group, and decreased significantly by esmolol in the esmolol group. The administered dose of esmolol was much less in the hydralazine-esmolol group than in the esmolol group. CONCLUSIONS: Our data suggest that hydralazine can enhance the efficacy of esmolol-induced controlled hypotension. It can reduce the requirement of esmolol and maintain a higher cardiac output during hypotension.
