Chemical constituents from ethyl acetate fraction of Swertia davidii
10.7501/j.issn.0253-2670.2019.18.003
- Author:
Tuan-Wu CAO
1
Author Information
1. Laboratory of Natural Medicine Research and Development in Wuling Mountain, School of Chemistry and Chemical Engineering, Yangtze Normal University
- Publication Type:Journal Article
- Keywords:
1-hydroxy-3,4,7,8-tetramethoxyxanthone;
Amaroswerin;
Deacetyl- centapicrin;
Iridoids;
Lactonic enamino ketones;
Swertia davidii Franch;
Xanthones
- From:
Chinese Traditional and Herbal Drugs
2019;50(18):4272-4276
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Swertia davidii. Methods: The chemical constituents of the ethyl acetate fraction from the whole plants of S. davidii (Gentianaceae) were investigated by various chromatographic methods including silica gel, ODS, semi-preparative HPLC and so on. Their structures were identified on the basis of NMR spectral data analysis and comparisons with the data reported in literatures. Results: Seventeen known compounds were separated and purified from the ethyl acetate fraction of this plant, which were identified as gentiocrucine (1), gentiocrucine A (2), gentiocrucine B (3), junipediol A (4), 1-hydroxy-3,4,7,8-tetramethoxyxanthone (5), 1,7,8-trihydroxy-3-methoxyxanthone (6), 1,8-dihydroxy-3,4,7-trimethoxyxanthone (7), 1,5,8-trihydroxy-3-methoxyxanthone (8), swertianolin (9), deacetylcentapicrin (10), amarogentin (11), amaroswerin (12), swertiamarin (13), gentiopicroside (14), oleanolic acid (15), daucosterol (16), and β-sitosterol (17). Conclusion: Compounds 1-6, 10, 12, 16, and 17 are isolated from S. davidii for the first time.
