Research progress in preclinical cancer models
10.3781/j.issn.1000-7431.2017.55.722
- Author:
Suyun YU
1
Author Information
1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Animal;
Drug evaluation;
Mice;
Models;
Neoplasms;
Preclinical;
Treatment outcome
- From:
Tumor
2017;37(8):878-882
- CountryChina
- Language:Chinese
-
Abstract:
Along with the increase in incidence and mortality of cancer, cancer has become a threat to human health. Therefore, more and more researchers have devoted themselves to the exploration of the pathogenesis of cancer and the related new therapies. Even so, only a few new anticancer drugs have been approved every year, the main reason is that the vast majority of new drugs has better preclinical effect but not has good clinical curative effect, so the reasonable application and innovation of preclinical evaluation system of antineoplastic drugs and the combination and unification of preclinical studies and clinical efficacy are urgent and important. It is well known that animal cancer models play an important role in the pathogenesis and treatment of cancer. This paper discusses the prospect of the most commonly used mouse models of cancer in preclinical studies and the challenges, and introduces the prospect of the new cancer models, in order to provide references for rational evaluation of clinical efficacy of drugs.
