New strategies and problems of affinity peptide in cartilage tissue engineering
10.3969/j.issn.2095-4344.3154
- Author:
Fu LIWEI
1
Author Information
1. Institute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA
- Publication Type:Journal Article
- Keywords:
Affinity peptide;
Cartilage;
Cartilage tissue engineering;
Materials;
Mesenchymal stem cells;
Review;
Scaffold
- From:
Chinese Journal of Tissue Engineering Research
2021;25(16):2569-2574
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: With the development of cartilage tissue engineering, affinity peptides have attracted some attention because of their special affinity to some key factors of cartilage tissue engineering. OBJECTIVE: To review the screening and identification of various affinity peptides and their application in cartilage tissue engineering. METHODS: The articles related to affinity peptides in CNKI, Wanfang, and PubMed were searched by computer from January 2000 to May 2020. “Affinity peptides, cartilage tissue engineering, mesenchymal stem cell, scaffold” in English and Chinese were used as key words. Finally, 66 articles were included for analysis. RESULTS AND CONCLUSION: Many polypeptides with specific amino acid sequence can bind with some cells, factors and molecules, and have affinity. According to different targets, they can be divided into cell affinity peptide, factor affinity peptide and extracellular matrix molecular affinity peptide. Affinity peptides have been used in cartilage tissue engineering through screening and identification to enhance the repair effect of tissue engineering by adhering fine cells, recruitment factors and molecules. In many strategies of biomimetic cartilage multilayer scaffolds, affinity peptides that interact with specific molecules play an important role in simulating the environment of normal cartilage. At the same time, with the development of cartilage tissue engineering technology, especially the application of computer-aided technology, it provides a new strategy for the use of affinity peptides. However, the residence time, degradation rate and degradation pathway of affinity peptides in vivo are relatively few, which need to be further understood.
