Study on mechanism of berberine on regulating glycogen metabolism by repairing glycogen structure
10.7501/j.issn.0253-2670.2020.16.020
- VernacularTitle: 小檗碱通过影响糖原结构调节肝糖代谢研究
- Author:
Lin MA
1
Author Information
1. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Berberine;
Db/db mice;
Diabetes;
Glycogen structure;
Liver glycogen;
Stability
- From:
Chinese Traditional and Herbal Drugs
2020;51(16):4259-4265
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of berberine regulating glycogen metabolism and its effect on glycogen structure. Methods: The db/db mice were used as diabetic mice to investigate the effect of berberine on blood glucose levels in db/db mice. The liver glycogen was extracted for SEC and TEM analysis to investigate the effect of berberine on liver glycogen and the mechanism of its effect. Results: Berberine significantly decreased the fasting blood glucose level and the insulin level in serum of db/db mice, and berberine repaired the damaged glycogen structure. Meanwhile, berberine decreased the expression of GP, GDBE, cAMP in liver tissue and the glucagon level in serum of db/db mice. Conclusion: Berberine regulated the cAMP/GP signaling pathway, improved hepatic glycogen structure in db/db mice, and repaired damaged glycogen structure, which may be one of the mechanisms for regulating hepatic glucose metabolism and improving symptoms of diabetes.
