Extraction optimization for Yinsangju solid beverage by orthogonal design and Box-Behnken design-response surface methodology
10.13220/j.cnki.jipr.2016.04.034
- Author:
Yue-Hui LI
1
Author Information
1. Hunan TCM Academy Yang Yonghua Inheritance Studio of the Famous TCIYI Experts
- Publication Type:Journal Article
- Keywords:
Box-Behnken design-response surface methodology;
Chlorogenic acid;
Orthogonal design;
Overall desirability;
Polysaccharide;
Yield of extract;
Yinsangju solid beverage
- From:
Journal of International Pharmaceutical Research
2016;43(4):761-767
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize extraction process of Yinsangju solid beverage(YSJ). Methods: The extraction of YSJ was preliminarie optimized through the orthogonal design,and then further optimized by Box-Behnken design-response surface with the overall desirability (OD) of chlorogenic acid and polysaccharide content and yield of extract as evaluation indexes. Results: The optimum extraction of orthogonal design was as follow: 10 times the amount of water,soaked 0.5 h,extracted 2 times,each time 1.5 h. The optimum extraction of Box-Behnken design was 10.82 times the amount of water,soaked 0.51 h,extracted 2 times,each time 1.77 h. Conclusion: The test results show that the Box-Behnken response surface method optimization of extraction process parameters is more precise and more detailed and predictability is good, and the product quality is improved.
