Isolation and identification of chemical constituents in the above-ground part of the plant Achyranthes bidentata BI.
10.13220/j.cnki.jipr.2020.06.008
- VernacularTitle: 牛膝地上部位化学成分的分离鉴定
- Author:
Zhi-Pin XU
1
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Achyranthes bidentata;
Chemical constituents;
Isolation and identification
- From:
Journal of International Pharmaceutical Research
2020;47(6):450-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents in the the above-ground part of the plant Achyranthes bidentata Bl. in Amarathaceae. Methods: The raw materials were extracted by heating with 70% ethanol, and the extract was prepared by column chromatography on Diaion HP-20, MCI Gel CHP-20P, Toyopearl HW-40, Sephadex LH-20, ODS and silica gel, coupled with the semi-preparative HPLC, to isolate the chemical constituents. The isolated compounds were identified according to their MS, 1H NMR and 13C NMR data. Results: Twenty one compounds were isolated and identified: haploperoside A(1), sweroside(2), 1'-O-benzyl-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(3), 2-ethyl-3-methyl-maleimide-N-β-D-glucopyranoside(4), 3-eth- ylidene-4-methyl-2, 5-pyrrolidinedione(5), methyl-5-hydroxy-2-pyridinecarboxylate(6), pericampylinone A(7), syringaresinol(8), episyringaresinol(9), methyl 3, 4-dihydroxybenzoate(10), 4-hydroxyphenylacetone(11), 3, 4-dihydroxyphenylacetic acid methyl ester(12), 2-(4-hydroxyphenyl)-ethanol(13), homovanillyl alcohol(14), dihydrosinapyl alcohol(15), 4-hydroxybenzoic acid (16), caffeic acid(17), 3-(4-hydroxy-3, 5-dimethoxyphenyl)propane-1, 2-diol(18), methyl(E)-3-(4-hydroxyphenyl)acrylate (19), trans-ferulic acid(20)and vanillic acid(21). Conclusion: Compounds 1-7 and 9-19 were isolated from the title plant for the first time.
