Progress and perspective of potential anti-coronavirus activity of phenothiazines
10.16438/j.0513-4870.2020-0554
- VernacularTitle:吩噻嗪类化合物潜在抗冠状病毒活性的研究进展
- Author:
Jun-yue WAN
1
;
Hua CHEN
2
;
Jie YIN
2
Author Information
1. China Pharmaceutical University, Nanjing 210000, China
2. NMPA Key Laboratory for Quality Research and Evaluation of Chemical Drugs, National Institutes for Food and Drug Control, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
coronavirus;
novel coronavirus;
phenothiazine;
antiviral agent;
antipsychotic agent
- From:
Acta Pharmaceutica Sinica
2020;55(11):2529-2534
- CountryChina
- Language:Chinese
-
Abstract:
Coronaviruses (CoVs) are associated with some mammalian infectious diseases, which have caused several outbreaks of respiratory system infectious diseases in recent years. There is no effective vaccine or approved drug treatment against coronaviruses, and the development of anti-coronavirus agents is an urgent priority. Phenothiazines are a class of antipsychotic drugs, which were found that they have some other biological activities, like promising antibacterial, antifungal, anticancer, antiviral, etc. They can be used for drug repurposing. This review summarizes current researches on the potential anti-coronavirus activity of phenothiazine, discusses the mechanisms and some research difficulties, and provides a foundation for developing anti-coronavirus drugs which use phenothiazine as the lead compound.
