Undifferentiated pleomorphic sarcoma of the mandible

Author: Bernar Monteiro BENITES ¹ ; Wanessa MIRANDA-SILVA ; Felipe Paiva FONSECA ; Claudia Regina Gomes CARDIM MENDES DE OLIVEIRA ; Eduardo Rodrigues FREGNANI
Author Information

1. Department of Oral Medicine, Hospital Sírio Libanês, São Paulo, Brazil
Publication Type:CASE REPORT
From:Journal of the Korean Association of Oral and Maxillofacial Surgeons 2020;46(4):282-287
CountryRepublic of Korea
Language:English
Abstract: Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindlecell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.