Minimally Invasive Gastric Electrical Stimulation Using a Newly Developed Wireless Gastrostimulator: A Pilot Animal Study
- Author:
Seung Han KIM
1
;
Hong Bae KIM
;
Hoon Jai CHUN
;
Hyuk Soon CHOI
;
Eun Sun KIM
;
Bora KEUM
;
Yeon Seok SEO
;
Yoon Tae JEEN
;
Hong Sik LEE
;
Soon Ho UM
;
Chang Duck KIM
Author Information
- Publication Type:Original Article
- From:Journal of Neurogastroenterology and Motility 2020;26(3):410-416
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Gastric electrical stimulation (GES) is a feasible modality for the treatment of gastroparesis; however, the presently available device requires invasive surgical implantation for long-term stimulation and repeated surgical procedure after a period of time. This study is aimed at developing a wireless miniature GES device and testing its endoscopic insertion in animal models.
Methods:Endoscopic gastric implantation of the GES device was performed on 5 healthy weaner pigs under general anesthesia. We created an endoscopic submucosal pocket and inserted the gastro-electrical stimulator. In vivo gastric slow waves were recorded and measured during electrical stimulation. A multi-channel recorder, called an electrogastrogram, was used to record the gastric myoelectrical activity in the study.
Results:The gastric slow waves on the electrogastrogram were more consistent with GES on the gastric tissues compared to no stimulation. The frequency-to-amplitude ratio was also significantly altered after the electrical stimulation.
Conclusions:GES is feasible with our minimally invasive wireless device. This technique has the potential to increase utilization of GES as a treatment alternative.
