Multiple Actinic Keratoses within Vitiliginous Patches in a Patient with Non-segmental Vitiligo
- Author:
Jaeyong SHIN
1
;
Do Young KIM
;
Sujin PARK
;
Ja Seung KOO
;
Seung Kyung HANN
;
Sang Ho OH
Author Information
1. Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- Publication Type:Case Report
- From:Korean Journal of Dermatology
2020;58(1):39-42
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 74-year-old man visited our department with complaints of multiple asymptomatic erythematous scaly crusted patches on the scalp. He had non-segmental vitiligo with the extent of over 20% of the body surface area for 30 years. Biopsies showed hyperkeratosis, foci of atypical, pleomorphic keratinocytes along the basal cell layer, and marked solar elastosis, consistent with actinic keratosis (AK). Melan-A and Fontana-Masson staining showed absence of melanin and melanocytes. Despite conflicting data on the prevalence of skin cancers in patients with vitiligo, it is known that vitiligo does not increase nor decrease the risk of skin cancer. Recent studies have reported that patients with vitiligo lesions show increased epidermal expression of wild-type p53 protein than healthy controls. However, a few cases of skin cancer have been reported in patients with vitiligo. Here, we report a case of AK developing in vitiligo lesions. Dermatologists should not overlook the possible occurrence of AK or skin cancers in sun-exposed vitiliginous skin.
