Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax
- Author:
Reyhane VARDIYAN
1
;
Daniyal EZATI
;
Morteza ANVARI
;
Nasrin GHASEMI
;
Alireza TALEBI
Author Information
- Publication Type:Original Article
- From:Clinical and Experimental Reproductive Medicine 2020;47(3):155-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methods:Thirty adult BALB/c mice were categorized into three groups. The mice in the control group (n=10) were not injected with any substance. The mice in the second group (n=10) received 10 mg/kg of formalin daily via an intraperitoneal injection, while those in the final group (n=10) were intraperitoneally injected daily with a dose of 10 mg/kg of formalin and 100 mg/kg of L-carnitine. All mice were kept in isolated cages for 31 days.
Results:The expression of Bax was significantly higher in the formalin-treated mice than in the mice of the control group, while the expression of Bcl-2 was significantly lower in the formalin-treated mice than in the control mice. Additionally, relative to control mice, Bcl-2 expression increased and Bax expression decreased in the mice administered both formalin and L-carnitine.
Conclusion:In this study, L-carnitine was shown to augment Bcl-2 expression and to reduce Bax expression, indicating that this compound may inhibit apoptosis. Due to its positive effects, L-carnitine can be used as a prophylactic treatment for people who routinely come into direct contact with formalin as an occupational hazard.
