Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.
10.3346/jkms.1999.14.6.671
- Author:
Sang Yong KWON
1
;
Je Jung LEE
;
Ik Joo CHUNG
;
Hyeoung Joon KIM
;
Moo Rim PARK
;
Hyung Seok KIM
;
Chang Soo PARK
Author Information
1. Department of Internal Medicine, National University Medical School, Kwangju Korea.
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Lymphoma, B-cell;
Histiocytosis, malignant;
Liver neoplasms;
Splenic neoplasms;
Neoplasms, multiple primary
- MeSH:
Adult;
Antigens, CD/analysis;
Antineoplastic Agents, Combined/therapeutic use;
Bone Marrow Cells/pathology;
Case Report;
Female;
Histiocytosis, Non-Langerhans-Cell/pathology;
Histiocytosis, Non-Langerhans-Cell/complications*;
Human;
Liver Neoplasms/radiography;
Liver Neoplasms/pathology;
Liver Neoplasms/complications*;
Lymphoma, B-Cell/radiography;
Lymphoma, B-Cell/pathology;
Lymphoma, B-Cell/complications*;
Splenic Neoplasms/radiography;
Splenic Neoplasms/pathology;
Splenic Neoplasms/complications*;
Splenomegaly/radiography;
Tomography, X-Ray Computed;
Tumor Markers, Biological/analysis
- From:Journal of Korean Medical Science
1999;14(6):671-674
- CountryRepublic of Korea
- Language:English
-
Abstract:
While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
