Effect of diarrhoea on Tacrolimus trough level in a post liver transplant patient
- Author:
Tan See Teng
1
;
Koon Boon Yoong
1
Author Information
- Publication Type:Journal Article
- From: The Medical Journal of Malaysia 2020;75(6):734-735
- CountryMalaysia
- Language:English
- Abstract: Tacrolimus, which bonds to an immunophilin, FK506 binding protein (FKBP) has emerged as one of the most widely used immunosuppressant post solid organ transplantation. It offers excellent patient survival rates post-transplantation and a lesser number of acute rejections as compared to cyclosporine. Tacrolimus has a narrow therapeutic window with overexposure leading to acute and chronic forms of nephrotoxicity. Remarkably few data have been published on the overexposure to tacrolimus following mild diarrhoea in post-transplant patients who received treatment with tacrolimus. We observed a post-liver transplant patient with increased trough level of tacrolimus during severe diarrhoea with no complications following a timely adjustment on the dose of tacrolimus.
