Application of bacteriophage technique in the treatment of alcoholic liver disease
DOI:10.3969/j.issn.1001-5256.2020.11.047
- VernacularTitle:噬菌体技术在酒精性肝病治疗中的应用
- Author:
Huan MA
1
;
Jing TONG
;
Bingyuan WANG
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, China
- Publication Type:Research Article
- Keywords:
hepatitis, alcoholic;
bacteriophages;
perforin;
therapeutics
- From:
Journal of Clinical Hepatology
2020;36(11):2606-2608
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic hepatitis (AH) is a severe alcohol-associated liver disease with a mortality rate as high as 40%. A recent study reveals that the exotoxin (cytolysin)-secreting gut bacterium Enterococcus faecalis is a critical factor for AH, which can be eliminated by bacteriophages, and therefore, the use of bacteriophages for the treatment of AH provide a new treatment option for AH. This article introduces this pioneering study and the knowledge of bacteriophages and cytolysin, so as to provide a theoretical basis for the clinical research on AH.
