Research progress on the role of Ang/Tie axis in angiogenesis and metastasis
10.16438/j.0513-4870.2020-0045
- VernacularTitle:Ang/Tie轴对肿瘤血管生成和转移作用的研究进展
- Author:
Cheng QIAN
1
;
Wei-wei ZHENG
1
;
Wei ZOU
1
;
Chun-mei YANG
1
;
Shan ZHANG
1
;
Yuan-yuan WU
1
;
Yin LU
2
;
Ai-yun WANG
2
Author Information
1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
angiopoietin;
tyrosine kinase receptor;
angiogenesis;
tumor metastatic;
therapeutic strategies
- From:
Acta Pharmaceutica Sinica
2020;55(10):2291-2297
- CountryChina
- Language:Chinese
-
Abstract:
The tumor contains abundant new vessels, which are unevenly distributed, irregular, and branch-disordered. Angiopoietin (Ang) and tyrosine kinase receptor Tie mediate stable maturation of angiogenesis. Ang1 mainly plays a role in promoting vascular stabilization, and Ang2 is highly expressed in vessels, which makes the structure and function of vessels abnormal. Leaked vessels provide opportunities for invasion and metastasis of circulating tumor cells. Targeting the Ang/Tie axis to correct the abnormal state of vessels and promote its normalization, combined with chemotherapy drugs or immunotherapy, play a synergistic effect against tumors. This article summarizes the role of Ang/Tie axis in tumor angiogenesis and metastasis, and it aims to provide new ideas and strategies for clinical treatment of tumors.
