Memory T cells: strategies for optimizing tumor immunotherapy.
10.1007/s13238-020-00707-9
- Author:
Qingjun LIU
1
;
Zhongjie SUN
2
;
Ligong CHEN
3
Author Information
1. School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China.
2. Newish Technology (Beijing) Co., Ltd., Xihuan South Road 18, Economic & Technical Development Zone, Beijing, 100176, China. szj@newishes.com.
3. School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China. ligongchen@tsinghua.edu.cn.
- Publication Type:Journal Article
- Keywords:
gut microbiota;
memory T cells;
metabolism;
tumor immunology
- From:
Protein & Cell
2020;11(8):549-564
- CountryChina
- Language:English
-
Abstract:
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.
