Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides.
10.1016/S1875-5364(20)60003-6
- Author:
Jia-Ning ZHAO
1
;
Ru-Feng WANG
1
;
Shu-Juan ZHAO
2
;
Zheng-Tao WANG
1
Author Information
1. The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: zhaoshujuan@shutcm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Biosynthesis;
Catalytic efficiency;
Ginsenosides;
Glycosyltransferase;
Protein engineering
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(9):643-658
- CountryChina
- Language:English
-
Abstract:
Ginsenosides are a series of glycosylated triterpenoids predominantly originated from Panax species with multiple pharmacological activities such as anti-aging, mediatory effect on the immune system and the nervous system. During the biosynthesis of ginsenosides, glycosyltransferases play essential roles by transferring various sugar moieties to the sapogenins in contributing to form structure and bioactivity diversified ginsenosides, which makes them important bioparts for synthetic biology-based production of these valuable ginsenosides. In this review, we summarized the functional elucidated glycosyltransferases responsible for ginsenoside biosynthesis, the advance in the protein engineering of UDP-glycosyltransferases (UGTs) and their application with the aim to provide in-depth understanding on ginsenoside-related UGTs for the production of rare ginsenosides applying synthetic biology-based microbial cell factories in the future.
