Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients.
- Author:
Eun Hee KIM
1
;
Ji Hee YU
;
Sang Ah LEE
;
Eui Young KIM
;
Won Gu KIM
;
Seung Hun LEE
;
Eun Hee CHO
;
Eun Hee KOH
;
Woo Je LEE
;
Min Seon KIM
;
Joong Yeol PARK
;
Ki Up LEE
Author Information
- Publication Type:Original Article
- Keywords: Cystatin C; Coronary artery disease; Diabetic nephropathies; Diabetes mellitus
- MeSH: Cardiovascular Diseases; Case-Control Studies; Coronary Artery Disease; Coronary Vessels; Creatinine; Cystatin C; Diabetes Mellitus; Diabetic Nephropathies; Humans
- From:Korean Diabetes Journal 2010;34(2):95-100
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy. METHODS: We conducted a case-control study to assess the relationship between serum cystatin C level and coronary artery disease in diabetic patients. Among 460 diabetic patients, 38 diabetic patients had CAD. The control group consisted of 38 diabetic patients who were matched to cases by age, sex, and presence/absence of diabetic nephropathy. Serum cystatin C level was measured in stored samples. RESULTS: Serum cystatin C level was significantly higher in patients with diabetic nephropathy, both in CAD and non-CAD patients. However, serum cystatin C level did not differ between CAD and non-CAD patients, regardless of diabetic nephropathy. CONCLUSION: Serum cystatin C level is a marker of renal dysfunction, but not coronary artery disease, in diabetic patients.
