Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota.
10.1016/S1875-5364(20)30060-1
- Author:
Ling CHEN
1
;
Man-Yun CHEN
2
;
Li SHAO
3
;
Wei ZHANG
2
;
Tai RAO
2
;
Hong-Hao ZHOU
2
;
Wei-Hua HUANG
4
Author Information
1. Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China.
2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
3. Department of Pharmacognosy, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410128, China.
4. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: endeavor34852@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
16S rRNA gene sequencing;
Colorectal cancer;
Ginsenosides;
Gut microbiota;
Panax notoginseng saponins
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(7):500-507
- CountryChina
- Language:English
-
Abstract:
Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly relieved AOM/DSS-induced colon tumorigenesis and development by reducing the disease activity index (DAI) scores and colon tumor load. The 16S rRNA data of fecal samples showed that the microbiome community was obviously destructed, while PNS could recover the richness and diversity of gut microbiota. Especially, PNS could increase the abundance of Akkermansia spp. which was significantly decreased in model group and negatively correlated with the progression of CRC. Moreover, ginsenoside compound K (GC-K) was evaluated on the effects of human CRC cells, which was the main bio-transformed metabolite of PNS by gut microbiota. Our data showed that PNS played important role in the prevention of the progression of CRC, due to their regulation on the microbiome balance and microbial bio-converted product with anti-CRC activity.
