Expression and Clinical Significance of EZH2 in Patients with Diffuse Large B Cell Lymphoma Accompanied by HBV Infection.
10.19746/j.cnki.issn.1009-2137.2020.03.022
- Author:
Yong-Tian ZHANG
1
;
Dan FENG
1
;
Ying WANG
1
;
De-Peng LI
1
;
Zhen-Yu LI
1
;
Ting-Ting QIU
2
;
Kai-Lin XU
3
,
4
Author Information
1. Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
2. Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,E-mail:qiutt2007@sina.com.
3. Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,E-mail:lihmd@
4. com.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
Cyclophosphamide;
Doxorubicin;
Enhancer of Zeste Homolog 2 Protein;
genetics;
Hepatitis B;
complications;
Hepatitis B virus;
Humans;
Lymphoma, Large B-Cell, Diffuse;
complications;
genetics;
Prognosis;
Retrospective Studies;
Rituximab;
Vincristine
- From:
Journal of Experimental Hematology
2020;28(3):855-860
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression and clinical significance of EZH2 in DLBCL patients accompanied by HBV infection.
METHODS:The clinicopathological data of 59 patients with DLBCL accompanied by HBV infection in our hospital from February 2015 to October 2017 were analyzed retrospectively. The patients were divided into HBV negative and HBV positive groups by serological testing before surgery. The expression of EZH2 was detected by immumohistochemical staining, and the clinicopathological characteristics and survival were analyzed and compared between these two groups.
RESULTS:There were 30 patients (50.8%) in the HBV negative group and 29 patients (49.2%)in the HBV positive group. The differences of age, LDH level and IPI score between two groups were statistically significant (P＜0.05). The expression of EZH2 in HBV- positive group was significantly higher than that in the HBV- negative group (P＜0.05), where the expression of EZH2 correlated with the expression of the BCL-6 (r=0.282, P＜0.05), especially in the GCB-DLBCL (r=0.549, P＜0.05). PFS was not significantly different between two groups of HBV (P＞0.05), while the PFS in the R-CHOP regimen group was higher than that in the CHOP regimen group (P＜0.05). COX multivariate analysis showed that both the chemotherapy regimen without R and the increased level of LDH were the risk factors affecting the prognosis of DLBCL patients (P＜0.05).
CONCLUSION:EZH2 highly expresses in HBV positive group, suggesting that the significance of EZH2 in DLBCL with HBV infection is worth further explore.
