Neutrophil-Lymphocyte Ratio as a Prognostic Predictor in Patients with Newly Diagnosed Angioimmunoblastic T Cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2020.03.024
- Author:
Yu-Qiong YANG
1
;
He-Sheng HE
1
;
Yan DAI
1
;
Xiao-Ke JIN
1
;
Jia-Jia LI
2
;
Chen HUANG
1
;
Jun HUANG
1
;
Jing QI
1
;
Jia-Wei YAN
1
;
Dong-Ping HUANG
3
,
4
Author Information
1. Department of Hematology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241000, Anhui Province, China.
2. Department of Pathology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241000, Anhui Province, China.
3. Department of Hematology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241000, Anhui Province, China,E-mail: hdp_9713@
4. com.
- Publication Type:Journal Article
- MeSH:
Humans;
Lymphocytes;
Lymphoma, T-Cell;
Middle Aged;
Neutrophils;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2020;28(3):866-871
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the prognostic evaluation value of neutrophil-lymphocyte ratio (NLR) in patients with newly diagnosed angioimmunoblastic T cell lymphoma (AITL).
METHODS:Clinical data of 39 patients with newly diagnosed AITL in our hospital from March 2010 to August 2018 were colleated and retrospective analyzied, and the relationship between NLR before treatment and the prognosis of AITL patients was analyzed.
RESULTS:Among 39 AITL patients, the median value of NCR was 5.43. Based on the cut-off value (5.43), all the patients were divided into 2 groups: high NLR group (5.43, n=20) and a low NLR group (＜5.43, n=19). The total effective rate of treatment was lower in the high NLR group as compered with low NLR group (P=0.041). Univariate analysis showed that, age ＞60 years old, extranodal involvement＞1 as well as high NLR were the independent risk factors that affected overall survival (OS) in newly diagnosed AITL patients. Multivariate Cox analysis showed that extranodal involvement＞1 and high NLR were the independent risk factors that affected OS in newly diagnosed AITL patients.
CONCLUSION:The NLR may be an independent prognostic factor in patients with newly diagnosed AITL. High NLR associated with poor prognosis.
