Clinical and Pathological Characteristics of Related-Renal Damage in Patients with POEMS Syndrome.
10.19746/j.cnki.issn.1009-2137.2020.03.043
- Author:
Wei-Min WANG
1
;
Ding-Ming WAN
1
;
Lin-Xiang LIU
1
;
Rong GUO
1
;
Ling SUN
1
;
Guo-Lan XING
2
;
Wei-Jie CAO
3
,
4
Author Information
1. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
2. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
3. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China,E-mail: caoweijie2003@
4. com.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Kidney;
Male;
Middle Aged;
POEMS Syndrome;
Paraproteinemias;
Renal Insufficiency;
Retrospective Studies
- From:
Journal of Experimental Hematology
2020;28(3):977-982
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigated the clinical and pathological characteristics of related-renal damage in patients with POEMS syndrome.
METHODS:Five patients diagnosed as POEMS syndrome in our hospital were selected. Their clinical manifestation, pathological characteristics of kidney and laboratory examination were analyzed retrospectively. Among the 5 patients, three males and two females with a median age of 50 years old. The mean interval before diagnosis was 13.0±7.2 months.
RESULTS:All the patients showed neuropathy, endocrinopathy, monoclonal plasma cell-proliferative disorder, skin changes and extravascular volume overload, in which 4 patients showed organomegaly. Proteinuria was found in 5 patients, and microhematuria was found in 4 patients. Moreover, 4 patients showed an elevated blood urea, while 2 patients showed creatinine elevation. 1 patient at chronic kidney disease (CKD)-G1 stage, 2 patients at CKD-G2 stage, and 1 patient at CKD-G3b stage, moreover, 1 patient at CKD-G5 stage. Endothelial injury and mesangial lesion were the main characteristics of renal pathology. 3 patients were pathologically diagnosed as thrombotic microangiopathy kidney damage, while 2 patients as light chain amyloidosis.
CONCLUSION:POEMS syndrome is a multi-systemic disease with complex clinical manifestations. 5 patients had different degrees of renal insufficiency. Endothelial injury and mesangial lesion are the main features of renal pathology.
