Renal Pathology and Cytogenetic Examination in Multiple Myeloma Patients with Renal Impairment--Retrospective Analysis.
10.19746/j.cnki.issn.1009-2137.2020.04.032
- Author:
Jia LYU
1
;
Yang-Xin HE
2
;
Jin-Cheng WANG
2
;
Ji-Ping SUN
1
;
Li-Yi XIE
1
;
Peng-Cheng HE
3
,
4
;
Ying CHEN
5
Author Information
1. Department of Nephrology, Nephrology Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province，China.
2. Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province，China.
3. Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province，China,E-mail: hepc@
4. com.
5. Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province，China,E-mail: chenying0717@foxmail.com.
- Publication Type:Journal Article
- MeSH:
Chromosome Aberrations;
Cytogenetic Analysis;
Cytogenetics;
Female;
Humans;
In Situ Hybridization, Fluorescence;
Male;
Multiple Myeloma;
Retrospective Studies
- From:
Journal of Experimental Hematology
2020;28(4):1272-1277
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the renal pathology and cytogenetic features in the multiple myeloma (MM) patients with renal impairment.
METHODS:The clinical data of newly diagnosed MM patients with renal impairment in our hospital from January 2009 to January 2019 were analyzed retrospectively, and the relationship between FISH results and results of renal pathological exanimation was analyzed statistically by using SPSS 20.0.
RESULTS:A total of 20 patients underwent renal biopsy, included 12 males and 8 females. FISH result showed that out of 20 patients, 7 cases presented interstitial nephritis, among which 3 cases were negative for FISH, and in the remaining cases the rate of IgH rearrangement, 1q21 amplification, RB1 deletion, D13S319 deletion, and P53 deletion detection was 42.86%, 28.57%, 28.57%, 28.57% and 14.29% respectively, the detection positive rate was statistically significantly lower as compared with total probe positive rate (P＜0.01). There were 6 cases of cast nephropathy, among which IgH rearrangement, the rate of 1q21 amplification, RB1 deletion, D13S319 deletion, and P53 deletion detection was 66.67%, 50%, 66.67%, 50% and 0% respectively. Compared with the total probe positive rate, there was no statistical significance (P＞0.05). There were 4 cases of acute tubular necrosis, among which the detection rates of IgH rearrangement, 1q21 amplification, RB1 deletion, D13S319 deletion, and P53 deletion was 100%, 50%, 50%, 25% and 25%, respectively. Compared with the total probe positive rate, there was no statistical significance (P＞0.05). There were one case of amyloidosis, and one case of tubular nephropathy with amyloidosis, the detection with 5 probes were all positive. One case of light chain deposition disease was positive for RB1 gene deletion + D13S319 gene deletion.
CONCLUSION:FISH in the MM patients with different renal pathological changes is characterized by heterogeneity, which can be used to predict the risk of renal damage and speculate possible renal pathological types to guide prognosis.
