Role of adrenergic receptors in tumorigenesis and development of glioma.
- Author:
Ye HE
1
;
Yu-Ge ZHU
2
;
Wei-Zhu LIU
3
;
Wen-Hua ZHANG
3
;
Bing-Xing PAN
3
;
Ping HU
4
,
5
Author Information
1. Center for Basic Medical Experiment, Nanchang University, Nanchang 330031, China.
2. The Center for Biotechnology and Biopharmaceutics, Institute of Translational Medicine, Nanchang University, Nanchang 330031, China.
3. Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China.
4. The Center for Biotechnology and Biopharmaceutics, Institute of Translational Medicine, Nanchang University, Nanchang 330031, China. canyhp@
5. com.
- Publication Type:Journal Article
- MeSH:
Brain Neoplasms;
pathology;
Carcinogenesis;
Cell Line, Tumor;
Cell Proliferation;
Gene Expression Regulation, Neoplastic;
Glioma;
pathology;
Humans;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Receptors, Adrenergic;
physiology;
Signal Transduction
- From:
Acta Physiologica Sinica
2020;72(2):235-242
- CountryChina
- Language:Chinese
-
Abstract:
Gliomas are malignant tumors with strong invasiveness. The current treatment strategy is surgical treatment assisted by a variety of radiotherapies, chemotherapies and immunotherapies. However, the curative efficacy is limited. Adrenergic receptor (AR) is an important stress hormone receptor, which is highly involved in the regulation of the tumorigenesis and progression of various tumors by activating different downstream signal transduction pathways. Recent studies have shown that AR is dysregulated in glioma cells and tissues, and plays an important role in a series of biological behaviors such as tumorigenesis, invasion and metastasis of glioma. This article reviews the research progress of AR in the field of glioma in recent years, which provides a theoretical basis for the prevention and treatment of glioma targeting the AR.
