Role of P21 in Resistance of Lung Cancer.
10.3779/j.issn.1009-3419.2020.101.16
- Author:
Tian FU
1
;
Ailing LIANG
1
;
Yongjun LIU
1
Author Information
1. Medical Molecular Diagnostics Key Laboratory of Guangdong, Dongguan 523808, China.
- Publication Type:Journal Article
- Keywords:
Drug resistance;
Lung neoplasms;
P21
- From:
Chinese Journal of Lung Cancer
2020;23(7):597-602
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the most common malignant tumor in the world with the highest incidence of deaths. In recent years, the treatment of lung cancer has made a significant breakthrough. However, as the tumor progresses, lung cancer cells inevitably acquire resistance and the efficacy of the treatment are greatly reduced. P21 protein plays a dual role in tumors, which not only regulates the cell cycle, induces apoptosis, inhibits cell proliferation, but also protects cells against apoptosis and promotes tumor cell resistance. This article reviews the research on P21 and lung cancer resistance, to provide new ideas for individualized treatment of lung cancer and overcoming lung cancer resistance.
