Experience in Using Jumihaidokuto and Orengedokuto for Skin Disorders Caused by Molecular Target Drugs
- VernacularTitle:分子標的治療薬による皮膚障害への十味敗毒湯と黄連解毒湯の使用経験
- Author:
Koki MORI
1
;
Tatsuya HIROSE
1
;
Koji TANAKA
1
;
Atsuko TAKEDA
1
;
Masahiro UNO
2
;
Hajime TAKAGI
3
Author Information
- Keywords: molecular targeted therapies; skin rashes; jumihaidokuto; orengedokuto
- From:Kampo Medicine 2020;71(1):30-35
- CountryJapan
- Language:Japanese
- Abstract: In some molecular targeted therapies, skin disorders including acne-like rashes or maculopapular rashes frequently appear, which are often clinically problematic. In Kampo medicine, it has been reported that the combination of jumihaidokuto and orengedokuto (hereinafter called JHT + OGT) is effective for acne. In this study, we report the experiences of JHT + OGT for the treatment of rashes caused by molecular targeted therapies. We extracted patients from June 2013 to June 2017 who took molecular targeted therapies and the treatment with JHT + OGT for skin rashes. The primary endpoint was severity of rashes before and after treatment by JHT + OGT (judged by CTCAE v4.0). In 22 patients (14 males and 8 females), the rashes after treatment with JHT + OGT significantly improved compared with those before treatment (from the median grade of 2 to 1 [p = 0.011]), with 14 cases of improvement, 6 cases of no change, and 2 cases of deterioration. It was suggested that JHT + OGT for skin rashes caused by molecular targeted therapies could be one of the treatment options.
