Frequent loss of CD10 expression in follicular lymphoma with leukaemic presentation
- Author:
Chen Shang-Wen
1
Author Information
1. Division of Hemato-Oncology, Department of Internal Medicine, Lioying Chi-Mei Hospital, Tainan, Taiwan
- Collective Name:Sheng-Tsung Chang; Yen-Chuan Hsieh; Chun-Chi Kuo; Hung-Chang Wu; Yin-Hsun Feng; Shih-Sung Chuang
- Publication Type:Journal Article
- Keywords:
B-cell leukaemia;
CD10;
fluorescence in situ hybridization;
follicular lymphoma;
leukaemic presentation;
small B-cell leukaemia;
Taiwan
- From:The Malaysian Journal of Pathology
2020;42(2):237-243
- CountryMalaysia
- Language:English
-
Abstract:
Follicular lymphoma (FL) is usually a nodal lymphoma expressing CD10, rarely with
leukaemic presentation (FL-LP). Materials and Methods: We searched for FL-LP in our institution
from 2000 to 2018 and characterised the neoplastic cells by flow cytometry, immunohistochemistry
and fluorescence in situ hybridization. Thirteen (6.1%) of 212 FL cases were FL-LP, all de novo
neoplasms. The leukaemic cells were small in 12 cases and large in one. All had concurrent FL,
mostly (92%; 12/13) low-grade. The single case with large leukaemic cells had a concurrent primary
splenic low-grade FL and a double-hit large B-cell lymphoma in the marrow. Results: CD10 was
expressed in the leukaemic cells in 38% (5/13) cases by flow cytometry and in 77% (10/13) cases in
tumours (p= 0.0471). IGH/BCL2 reciprocal translocation was identified in 85% (11/13) cases. Most
patients were treated with chemotherapy. In a median follow-up time of 36 months, nine patients
were in complete remission. The 2- and 5-year survival rates were at 100% and 83%, respectively.
In this study, we characterised a series of de novo FL-LP in Taiwan. All patients had concurrent
nodal and/or tissue tumours, which might suggest that these patients seek medical help too late.
Conclusion: The lower CD10 expression rate by flow cytometry than by immunohistochemistry
might be due to different epitopes for these assays. Alternatively, loss of CD10 expression might play
a role in the pathogenesis of leukaemic change. The clinical course of FL-LP could be aggressive,
but a significant proportion of the patients obtained complete remission with chemotherapy.
- Full text:5.2020my01066.pdf
