Advances in research of signaling pathway-related microRNA in osteosarcoma
10. 11904/j. issn. 1002-3070. 2019. 06. 013
- VernacularTitle:信号通路相关的microRNA在骨肉瘤中的研究进展
- Author:
Susu LI
1
,
2
;
Chunxiang ZHOU
Author Information
1. 南京中医药大学(南京 210046)
2. 南京明基医院
- Keywords:
MicroRNA;
Osteosarcoma;
Treatment;
Signaling pathway
- From:
Practical Oncology Journal
2019;33(6):544-548
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is a relatively common malignant tumor originating from bone tissue,which occurs in children and adolescents. In recent years,the role of microRNA in the development of bone tumors has become a hot topic. Numerous studies have shown that microRNA can affect the expression of target genes through MAPK/ERK,PI3K/AKT,Wnt/β-catenin and other signaling pathways,thereby regulating the biological functions such as proliferation,differentiation and invasion of tumor cells,and the develop-ment of osteosarcoma. MicroRNA is closely related to the development,clinical treatment and prognosis of osteosarcoma.
