Clinical characteristics and laboratory features of primary Sjögren's syndrome with positive anticentromere antibody
10.16571/j.cnki.1008-8199.2020.08.011
- VernacularTitle: 抗着丝点抗体阳性的原发干燥综合征临床及实验室特征分析
- Author:
Hong-bo SHI
1
;
Jun-nan LV
1
Author Information
1. Department of Laboratory Medicine, the First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning, China
- Publication Type:Journal Article
- Keywords:
anticentromere antibody；primary Sjögren’s syndrome；clinical manifestation；autoantibody
- From:
Journal of Medical Postgraduates
2020;33(8):839-843
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveAnti-centromere antibody(ACA)-positive primary Sjögren's syndrome (SS) is considered a subtype of SS, and the clinical significance of ACA in SS has not been totally clear. The purpose of this study is to investigate the clinical manifestation and laboratory examination characteristics of primary Sjgren's syndrome(pSS) with anticentromere antibody(ACA). MethodsThe clinical data of 88 pSS patients admitted to the Department of Rheumatology Immunology of the First Affiliated Hospital of Dalian Medical University were collected, including 43 ACA positive patients (ACA positive group) and 45 ACA negative patients (ACA negative group). The clinical characteristics and laboratory indicators of each group were compared.ResultsThe mean age of pSS patients with ACA positive (63.0±11.1) was higher than that of pSS with ACA negative (57.7±12.5), and in the group of ACA (+) pSS, Renand's phenomenon (RP) was more frequent（P<0.05). The pSS patients with ACA presented a significantly higher prevalence of PBC than those of pSS with ACA negative (P<0.05). Compared with ACA(-) pSS group, the serum levels of AST, ALP, GGT and IgM were higher in ACA(+) pSS group (P<0.05), and the serum levels of IgG and IgA were lower than those of ACA(-) pSS group. In the group of ACA(+) pSS, the positive rates of anti-SSA, anti-SSB antibody and RF were all lower (P<0.05), while the positive rate of anti-mitochondrial antibody (AMA) was higher (P<0.05). While in terms of hypokalemia, interstitial pneumonia, pulmonary fibrosis, abnormal renal function, hematologic involvement and merge tumor, there was no statistical difference (P>0.05).ConclusionThe clinical characteristics and laboratory features of pSS patients with positive ACA differ from those with negative antibody. pSS patients with ACA positive were older, they had more Reynolds phenomenon, liver injury and combined PBC.
