Study on pharmacodynamics and safety of self-made compound ketoconazole ointment
10.12206/j.issn.1006-0111.201909078
- VernacularTitle:自制复方酮康唑软膏的药效学和安全性研究
- Author:
Jia YAN
1
;
Bo WU
2
;
Chun TAO
1
;
Hongtao SONG
1
Author Information
1. Department of Pharmacy, No. 900 Hospital of Joint Logistic Support Force of the PLA, Fuzhou 350025, China.
2. Department of Pharmacy, No. 900 Hospital of Joint Logistic Support Force of the PLA, Fuzhou 350025, China;College of Pharmacy, Fujian Medical University, Fuzhou 350108,China.
- Keywords:
ketoconazole;
mupirocin;
mometasone furoate;
ointment;
antibacterial property;
safety
- From:
Journal of Pharmaceutical Practice
2020;38(4):322-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacodynamics and safety of the self-made compound ketoconazole ointment. Methods Using the disk diffusion test, 6 kinds of fungi and 2 kinds of bacteria were selected to investigate the effect of the self-made ointment and 3 commercial products on the diameter of the bacteriostatic circle. In addition, the skin irritation and skin allergies of the single and multiple applications were used to evaluate the safety of the self-made ointment. Results The self-made ointment was similar to the commercial products containing ketoconazole. They all showed remarkable bacteriostatic circle against the 6 kinds of fungi. For pseudomonas aeruginosa, none of the preparations contributed to visible bacteriostatic circle. For staphylococcus aureus, the bacteriostatic circle of the self-made ointment was similar to that of commercial mupirocin ointment and was significantly larger than other commercial products. After the treatment with the self-made ointment, the score of the skin irritation was below 0.5 and the sensitization rate was 0. There was no difference in tissue structure between treated and normal skin. Conclusion The self-made compound ketoconazole ointment has better safety and better antibacterial property than the commercial products. It is expected to be used for the treatment of superficial skin fugle infections.
