Research progress on CXC chemokines and their receptors in tumor microenvironment
10.3872/j.issn.1007-385x.2020.07.001
- VernacularTitle:肿瘤微环境中CXC型趋化因子及其受体的研究进展
- Author:
XUE Zhaojun
1
;
JIA Yuan
1
;
ZHANG Junping
1
Author Information
1. Cancer Center, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan
- Publication Type:Journal Article
- Keywords:
CXC chemokine;
chemokine receptor;
tumor microenvironment;
tumor;
immunotherapy;
forecast
- From:
Chinese Journal of Cancer Biotherapy
2020;27(7):715-724
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Chemokines are small secreted proteins produced by cancer and stromal cells. Chemokine receptors are also expressed on
the surface of tumor cells and stromal cells. Chemokines bind to their homologous receptors to regulate tumor growth directly and
indirectly, including direct regulation of tumor proliferation and metastasis by activating signal pathway, indirect regulation of tumor
through acting on vascular endothelial cells and regulating immune response by coordinating the migration and localization of immune
cells in tissues. Chemokines can be divided into four categories: CXC, CC, CX3C and C, among which CXC and CC are the most
studied subtypes. In view of the fact that CXC chemokines and their receptors play a wide range of roles in malignant tumors and are
closely related to the immune system, they are expected to become potential therapeutic targets, to improve tumor immune response by
combining with immune checkpoint inhibitors to act in tumor microenvironment (TME). This paper reviews the research progress
on chemokine/chemokine receptor axis of CXC subtypes, including the basic biological characteristics of tumor-promoting axis
CXCR2/CXCLs, CXCR4/CXCL12 and tumor-suppressing axis CXCR3/CXCL9-11, their direct effect on tumor, indirect effect on
TME, targeted therapy and prognostic significance of the receptors and ligands contained in these three axes.
- Full text:20200701.pdf
